ORAL DOSING
Once-daily dosing option to accommodate your patients1
Patients should:
Avoid food consumption for at least 2 hours before and 1 hour after taking SCEMBLIX
Swallow SCEMBLIX whole—do not break, crush, or chew SCEMBLIX tablets
DOSAGE MODIFICATIONS
Dosage reductions and modifications
DOSAGE REDUCTIONS
For the management of ARs, reduce the SCEMBLIX dose as described in the table below.
• First reduction: 40 mg qd OR 20 mg bid
• Subsequent reduction: Permanently discontinue SCEMBLIX in patients unable to tolerate 40 mg qd OR 20 mg bid
DOSAGE MODIFICATIONS FOR THE MANAGEMENT OF ADVERSE REACTIONS
ANC, absolute neutrophil count; AR, adverse reaction; bid, twice daily; CTCAE, Common Terminology Criteria for Adverse Events; Ph+ CML-CP, Philadelphia chromosome–positive chronic myeloid leukemia in chronic phase; PLT, platelets; qd, once daily; ULN, upper limit of normal.
aBased on Common Terminology Criteria for Adverse Events (CTCAE) v4.03.